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Polycomb Complex
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For Research Use Only. Not For Clinical Use.
Background
Polycomb Group (PcG) complexes are highly conserved, multi-protein epigenetic regulators that play a crucial role in gene silencing and maintaining cell identity throughout development, from early embryogenesis to adult tissue homeostasis. They operate by modifying chromatin structure, thereby ensuring that genes that should remain "off" in specific cell types or developmental stages stay repressed, even after the initial developmental cues have faded. This stable, heritable gene silencing is critical for proper cell differentiation and tissue development.