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RAPGEF1
Anti-RAPGEF1 Recombinant Antibody Products
- Recombinant Mouse Anti-Human RAPGEF1 Antibody (MOB-1414MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Mouse Anti-NHP RAPGEF1 Recombinant Antibody (clone OTI3H5) (VS-1024-XY439)
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- Species Reactivity: Human, Non-human primate
- Type: Mouse IgG2b
- Application: WB, IF
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For Research Use Only. Not For Clinical Use.
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells, Microglial cells, Langerhans cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with HCK (via SH3-binding sites) (PubMed:14551197). Interacts with CRK (via SH3-binding sites) (PubMed:8662907).
Molecular function
Guanine-nucleotide releasing factor
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