REPS2

Recombinant Antibody Products

Anti-REPS2 Recombinant Antibody Products

Hi-Affi™ Recombinant Rabbit Anti-REPS2 Monoclonal Antibody (DS3050AB) (MOR-3050)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)

Immune cell specificity

Group enriched (neutrophil, basophil, eosinophil)

Cell line specificity

Cell line enhanced (HDLM-2, Karpas-707, RH-30, RPMI-8226)

Interaction

Interacts with EPN1; the interaction is direct (PubMed:10393179, PubMed:10557078). Interacts with EPS15; the interaction is direct (PubMed:10393179). Interacts with EPS15L1 (PubMed:10393179). Interacts with RALBP1; can form a ternary complex with activated Ral (RALA or RALB) (PubMed:9422736). Interacts with ASAP1; the interaction is direct and this complex can bind paxillin (PubMed:12149250). Also forms a ternary complex with RALBP1 and ASAP1 (PubMed:12149250). Interacts with GRB2 (PubMed:9422736).

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