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RICTOR
Loading...Anti-RICTOR Products
- Recombinant Mouse Anti-Human RICTOR Antibody (MOB-1650MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human, Monkey, Mouse
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Monkey
- Type: Mouse IgG1
- Application: WB, ELISA
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- Mouse Anti-RICTOR Recombinant Antibody (clone 7B3) (VS3-XY1372)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC, IHC, ICC
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- Rabbit Anti-NHP RICTOR Recombinant Antibody (VS-1024-XY448) (VS-1024-XY448)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Rabbit IgG
- Application: WB
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- Mouse Anti-RICTOR Monoclonal Antibody (VS7-0425-WR781) (VS7-0425-WR781)
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- Species Reactivity: Human, Mouse, Monkey
- Type: Mouse IgG
- Application: WB, IHC-P, IF, ICC, FC, ELISA
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- Anti-RICTOR Immunohistochemistry Kit (VS-0325-XY1921)
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- Species Reactivity: Human, Mouse, Rat
- Target: RICTOR
- Application: IHC
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- Anti-Rat RICTOR Immunohistochemistry Kit (VS-0525-XY6125)
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- Species Reactivity: Human, Rat
- Target: RICTOR
- Application: IHC
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For Research Use Only. Not For Clinical Use.
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex; interaction with MTOR is enhanced by deubiquitination of RICTOR by USP9X (PubMed:15268862, PubMed:17461779, PubMed:17599906, PubMed:33378666). Interaction with MAPKAP1 is not enhanced by RICTOR deubiquitination by USP9X (PubMed:33378666). Interacts with CCDC28B (PubMed:23727834). Interacts with NBN (PubMed:23762398). Interacts with PRR5L (PubMed:17461779, PubMed:21964062). Interacts with SIK3 (PubMed:30232230). Interacts with NCKAP1L (PubMed:32647003). Interacts with kinases GSK3A and GSK3B; the interactions lead to phosphorylation of RICTOR at 'Thr-1695' which facilitates its FBXW7-mediated ubiquitination and subsequent degradation (PubMed:25897075). Interacts with FBXW7; the interaction is enhanced by GSK3-mediated phosphorylation of 'Thr-1695' and results in RICTOR ubiquitination and degradation (PubMed:25897075). Interacts with USP9X; the interaction results in deubiquitination of RICTOR and protection from proteasomal degradation, thus promoting mTORC2 complex assembly (PubMed:33378666). (Microbial infection) Interacts with vaccinia virus protein F17; this interaction dysregulates mTOR.
Molecular function
Developmental protein
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Related Signaling Pathways
mTOR Signaling Pathway