RNF19A
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Loading...- Mouse Anti-RNF19A Recombinant Antibody (RN1007) (VS-0326-YC1007)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Karpas-707)
Interaction
Interacts with UBE2L3 and UBE2L6. Interacts with transcription factor Sp1. Interacts with VCP, CASR, SNCAIP and with some SOD1 variants which cause amyotrophic lateral sclerosis, but not with wild-type SOD1.
Molecular function
Transferase
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