Anti-ROS1 Recombinant Antibody Products

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Anti-ROS1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers a comprehensive suite of recombinant antibodies targeting ROS1, engineered through rigorous molecular design processes to ensure high specificity and binding affinity across standardized methodologies, including western blotting, ELISA, and flow cytometry. Verified for functional consistency, these antibodies are meant to speed up treatment development processes by allowing exact probing of ROS1 signaling pathways. These instruments have great promise to propel translational research in ROS1-driven oncogenesis forward by simplifying the path of targeted treatments towards clinical use.

ROS1: An Investigational Therapeutic Target for Malignant Tumors

ROS1, a proto-oncogene encoding a transmembrane receptor tyrosine kinase of the insulin receptor family, drives oncogenic signaling through structural alterations such as mutations or chromosomal rearrangements that constitutively activate its kinase domain. These dysregulated events promote tumorigenesis across multiple malignancies. While pharmacological targeting of ROS1 kinase activity has yielded clinically approved inhibitors, the mechanisms governing treatment resistance and dose-limiting toxicities remain poorly characterized. A comprehensive dissection of ROS1’s signaling networks and context-dependent roles in oncogenesis is therefore imperative to advance therapeutic strategies.

Alternative Names

Proto-oncogene tyrosine-protein kinase ROS; MCF3; ROS; c-ros-1; ROS proto-oncogene 1; receptor tyrosine kinase.

Background

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Anti-ROS1 rAb Products

Creative Biolabs' anti-ROS1 recombinant antibodies are precision-engineered for enhanced target engagement and specificity, featuring multifunctional molecular architectures compatible with applications ranging from immune response profiling to oncogenic mechanism elucidation and therapeutic candidate screening. Rigorous bioprocessing protocols, complemented by multi-tiered analytical validation (e.g., structural epitope characterization and ligand interaction analyses), ensure batch-to-batch reproducibility. This methodological integration of protein engineering with standardized production processes yields biologics with optimized binding kinetics and discriminatory selectivity—attributes essential for mechanistic studies and therapeutic innovation.

Table 1. Featured anti-ROS1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs' recombinant anti-ROS1 antibodies show great antigen selectivity and binding kinetics engineered by a multiphase quality assurance system including process optimization. Their strong performance is confirmed by thorough functional characterisation across orthogonal assay methods supplemented with batch-to-batch repeatability confirmation by multimodal analytics.

Customer Reviews

Excellent

Je***j
Mouse Anti-ROS1 Recombinant Antibody (MOB-0237F) (MOB-0237F)

For our IHC labelling of lung cancer tissue samples, we have been using the anti-ROS1 antibody from Creative Biolabs; the findings have been somewhat consistently clean. The signal's remarkable purity makes simple ROS1-positive cell identification possible. Especially in terms of dependability and specificity, this antibody really distinguishes itself from other ones we have utilized. This is now a basic part of our diagnostic research approach.

1/Nov/2023

Excellent

He***y
Recombinant Mouse anti-Human ROS1 Monoclonal antibody (5-7H) (MOB-1052CT)

Particularly for western blotting, this antibody has been a huge help for our cell signaling research aiming at ROS1 activation. The continuous strong bands I often get at the predicted molecular weight greatly satisfy me. To lower non-specific binding in our particular cell line, we had to maximize the dilution; hence, I received great technical assistance from Creative Biolabs in providing direction. For our in vitro studies, this antibody consistently and generally works well.

13/Apr/2024

Excellent

Ho***i
Recombinant Mouse anti-Human ROS1 Monoclonal antibody (5-7H) (MOB-1052CT)

We utilized the anti-ROS1 antibody from Creative Biolabs in our preclinical mouse model research to evaluate targeted treatment options. We effectively detected notable and specific ROS1 protein binding in tumor tissues; however, in vivo treatments needed careful adjustment of dose and detection methods. Knowing that our long-term study will have batch homogeneity gave us additional confidence. Although the antibody worked well, compared to the in vitro studies, the in vivo study required additional changes.

10/Jun/2024

rAb Production

Creative Biolabs offers researchers all across the globe a consistent and reliable supply of premium anti-ROS1 recombinant antibodies as a trusted worldwide partner. Our painstakingly created and verified antibodies guarantee exceptional quality and performance throughout a wide spectrum of research uses by use of modern recombinant technologies. Our commitment is in accelerating scientific progress by providing researchers with dependable reagents necessary to investigate the complexities of ROS1 signaling under several biological contexts.

Featured Anti-ROS1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-ROS1 recombinant antibody production.

Fig.3 Gram-scale anti-ROS1 recombinant antibody production.

rAb Modalities

Creative Biolabs provides premium, customized anti-ROS1 recombinant antibodies that are designed to address unique research requirements. These antibodies are carefully made to fit the particular requirements of research communities in local, national, and worldwide settings and come in many forms.

Fig.4 Full-length anti-ROS1 recombinant antibody production and modalities.

ROS1-Targeted Drug Information

Table 2. Public drug targeting ROS1.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Leveraging a wealth of knowledge in antibody development and production, Creative Biolabs provides ROS1 recombinant antibodies that consistently yield exceptional outcomes across a variety of research applications. We are committed to the quality and reliability of our antibodies and encourage researchers exploring the importance of ROS1 to reach out for tailored pricing information that aligns with their specific research needs.

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