Anti-ROS1 (clone W24V35) Recombinant Antibody Coupled Liposome (VS-1024-FY36)
CAT#: VS-1024-FY36
The anti-ROS1 antibody-conjugated liposomes represent an emerging targeted therapy for lung cancer. Liposomes, as drug delivery vehicles, can enhance the targeting ability of antibodies while demonstrating direct effects on ROS1-overexpressing cells in lung cancer treatment. This combination may improve therapeutic efficacy and reduce damage to normal cells. Research in this field is continuously on the rise.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72424/1496_D3_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows moderate membranous positivity in cells in glomeruli.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49098/ihc_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49098/112722_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Nuclear Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49098/112722_A_4_6.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (GAMG, HSkMC, hTCEpi, LHCN-M2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000047936-ROS1
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More Infomation
Specifications
- Potential Clinical Applications
- Lung cancer
Product Composition
- Clone
- W24V35
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse monoclonal antibody specifically designed to recognize and bind to the ROS1 protein. ROS1, or ROS proto-oncogene 1, is a receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell growth, differentiation, and signaling pathways.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ROS1
- Introduction
- This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
- Alternative Names
- ROS Proto-Oncogene 1, Receptor Tyrosine Kinase; V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1; C-Ros Oncogene 1, Receptor Tyrosine Kinase; Proto-Oncogene C-Ros-1; MCF3; ROS; V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian); ROS Proto-Oncogene 1, Receptor Tyrosine Kinase
- Full Name
- ROS Proto-Oncogene 1, Receptor Tyrosine Kinase
- Gene ID
- 6098
- UniProt ID
- P08922
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated.
Probably autophosphorylates.
Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation.
Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity).
Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.
- Protein Refseq
- XP_006715611.1; XP_011534351.1; XP_011534352.1; XP_011534353.1; XP_011534355.1
- Function
- Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium.
NELL2 is an endogenous ligand for ROS1.
Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity).
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Datasheet
MSDS
COA
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See other products for "ROS1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1052CT | Recombinant Mouse anti-Human ROS1 Monoclonal antibody (5-7H) | FC, ICC, IF, IHC-Fr, IHC-P, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3098 | Hi-Affi™ Recombinant Rabbit Anti-ROS1 Monoclonal Antibody (DS3098AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0237F | Mouse Anti-ROS1 Recombinant Antibody (MOB-0237F) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1278 | Recombinant Mouse Anti-ROS1 Antibody (clone 4D9-6A7-10G9) | IHC-P | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6182 | Anti-ROS1 Immunohistochemistry Kit | IHC |
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