Anti-ROS1 (clone W24V35) Recombinant Antibody Coupled Liposome (VS-1024-FY36) (CAT#: VS-1024-FY36)

• Potential Clinical Applications
• Lung cancer

• Clone
• W24V35

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant mouse monoclonal antibody specifically designed to recognize and bind to the ROS1 protein. ROS1, or ROS proto-oncogene 1, is a receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell growth, differentiation, and signaling pathways.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• ROS1

• Introduction
• This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.

• Alternative Names
• ROS Proto-Oncogene 1, Receptor Tyrosine Kinase; V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1; C-Ros Oncogene 1, Receptor Tyrosine Kinase; Proto-Oncogene C-Ros-1; MCF3; ROS; V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian); ROS Proto-Oncogene 1, Receptor Tyrosine Kinase

• Full Name
• ROS Proto-Oncogene 1, Receptor Tyrosine Kinase

• Gene ID
• 6098

• UniProt ID
• P08922

• Sequence Similarities
• Belongs to the protein kinase superfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Phosphorylated.
  Probably autophosphorylates.
  Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation.
  Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity).
  Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.

• Protein Refseq
• XP_006715611.1; XP_011534351.1; XP_011534352.1; XP_011534353.1; XP_011534355.1

• Function
• Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium.
  NELL2 is an endogenous ligand for ROS1.
  Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity).

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