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RXFP1

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Protein class

G-protein coupled receptors, Transporters

Predicted location

Membrane

Single cell type specificity

Group enriched (Glandular and luminal cells, Excitatory neurons, Endometrial ciliated cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (EFO-21, HEL, RPTEC TERT1, THP-1)

Interaction

Interacts with C1QTNF8.

Molecular function

G-protein coupled receptor, Receptor, Transducer

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