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    RYR3

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene.
    Protein class

    Plasma proteins

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enriched (Astrocytes)

    Immune cell specificity

    Immune cell enriched (basophil)

    Cell line specificity

    Cell line enhanced (A549, RH-30, RPTEC TERT1, SuSa)

    Interaction

    Homotetramer. Heterotetramer with RYR2. Interacts with CALM (By similarity). Interacts with FKBP1A. Interacts with SELENON (By similarity).

    Molecular function

    Calcium channel, Calmodulin-binding, Ion channel, Ligand-gated ion channel, Receptor

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