S100A10

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For Research Use Only. Not For Clinical Use.


Background

S100A10 acts as a cellular chaperone for hepatitis B (Hep B) virus polymerase. Hep B virus polymerase normally localizes to the cytoplasm only, though in the presence of S-100A10 a portion relocates to the nucleus, implying a role for S100A10 and intracellular calcium in the process of viral replication. Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Protein class

Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Pancreatic endocrine cells, Langerhans cells, Distal enterocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (OE19)

Interaction

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (PubMed:9886297). Interacts with SCN10A (By similarity). Interacts with TASOR (By similarity).

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