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For Research Use Only. Not For Clinical Use.
Cancer-related genes, Plasma proteins
Intracellular, Secreted (different isoforms)
Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Squamous epithelial cells, Urothelial cells, Basal prostatic cells)
Immune cell enriched (basophil)
Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi)
Homodimer (PubMed:28202711). Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with COP1; this interaction leads to proteasomal degradation. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711).