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SLC22A12
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Proximal tubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Interacts with PDZK1.
More Types Infomation