SLC6A4
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Loading...- Mouse Anti-SLC6A4 Recombinant Antibody (clone 15B8); Fab fragment (PABJ-0101-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Rabbit Anti-SLC6A4 Recombinant Antibody (VS-0223-WK61) (VS-0223-WK61)
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- Derivation: Rabbit
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: IHC, IHC-P
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- Mouse Anti-SLC6A4 Recombinant Antibody (clone 15B8); scFv Fragment (PABJ-0101-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Anti-SLC6A4 Immunohistochemistry Kit (VS-0525-XY6693)
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- Species Reactivity: Human
- Target: SLC6A4
- Application: IHC
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- Mouse Anti-SLC6A4 Antibody (15B8), CHO Stable Cell Pool (VS-1025-QX485)
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- Host Species: Mouse
- Target: SLC6A4
- Species Reactivity: Human
- Antibody Type: Mouse Fab
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For Research Use Only. Not For Clinical Use.
Background
Enables monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and nitric-oxide synthase binding activity. Involved in several processes, including brain morphogenesis; serotonin uptake; and social behavior. Acts upstream of or within cellular response to organic substance. Located in focal adhesion and synapse. Is expressed in several structures, including early conceptus; liver; nervous system; ovary; and polar body. Used to study autism spectrum disorder and sudden infant death syndrome. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4).
Protein class
FDA approved drug targets, Human disease related genes, Metabolic proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Cytotrophoblasts, Syncytiotrophoblasts, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BEWO, CACO-2, Hep G2)
Interaction
Monomer or homooligomer (By similarity). Interacts with TGFB1I1 (PubMed:16803896). Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly (PubMed:16870614). Interacts with ITGAV:ITGB3 (By similarity).
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