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SOCS1
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (dendritic cells, T-cells, Adipocytes)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enriched (HDLM-2)
Interaction
Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (ELOB and ELOC). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with AXL, CUL2 and FGFR3. Interacts with INSR (By similarity). Interacts with TRIM8 (PubMed:12163497). Interacts with DCUN1D1 (PubMed:23401859). Interacts with IFNGR1 (By similarity).
Molecular function
Signal transduction inhibitor
More Types Infomation
- Recombinant Anti-Human SOCS1 Antibody scFv Fragment (MOB-3569z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, Neut, FuncS
- Recombinant Anti-Human SOCS1 Antibody Fab Fragment (MOB-3569z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: Neut, WB, FuncS
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.