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Mouse Anti-SOCS1 Recombinant Antibody (clone 5C3) (CAT#: VS3-WK1602)

This antibody is a mouse recombinant antibody against human SOCS1, which functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. The clone 5C3 can be used in WB analysis at a dilution of 1/1000-1/2000 and IHC analysis at a dilution of 1/50-1/200.


See more Engineered Antibody products for SOCS1
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Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/74108/1537_C7_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10355/33324_B_9_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10355/33324_A_8_3.jpg
Figure 4 Liver
Figure 4 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10355/33324_A_9_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10355/33324_A_9_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10355/33324_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10355/33324_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enriched (HDLM-2)
Figure 8 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185338-SOCS1

Specifications

  • Immunogen
  • Synthesized peptide derived from human SOCS-1
  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Human SOCS1
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • 5C3
  • Applications
  • IHC-P, WB
  • Conjugate
  • Unconjugated

Product Property

  • Clonality
  • Monoclonal
  • Purification
  • Protein G affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Aggregation
  • < 5%
  • Format
  • Liquid
  • Concentration
  • 1 mg/mL
  • Buffer
  • PBS, 0.5% BSA, 50% Glycerol
  • Preservative
  • 0.02% Sodium Azide
  • Storage
  • Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • IHC-P: 1/50-1/200
    WB: 1/1000-1/2000

Target

  • Alternative Names
  • Suppressor Of Cytokine Signaling 1; STAT-Induced STAT Inhibitor 1; Tec-Interacting Protein 3; SOCS-1; SSI-1; TIP-3; SSI1; TIP3
  • Long Name
  • Suppressor Of Cytokine Signaling 1
  • Sequence Similarities
  • Belongs to the SOCS1 family.
  • Cellular Localization
  • Cytoplasmic vesicle, Nucleus
  • Function
  • Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF).

Recommended Products

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "SOCS1"

Recombinant Antibody

CAT Product Name Application Type
MOB-3569z Mouse Anti-SOCS1 Recombinant Antibody (MOB-3569z) WB, IP, IF, ELISA Mouse IgG2a, κ

Fab Fragment Antibody

CAT Product Name Application Type
MOB-3569z-F(E) Recombinant Anti-Human SOCS1 Antibody Fab Fragment Neut, WB, FuncS Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-3569z-S(P) Recombinant Anti-Human SOCS1 Antibody scFv Fragment ELISA, WB, Neut, FuncS scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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