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SP140
Anti-SP140 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (B-cells, Plasma cells, T-cells, NK-cells, dendritic cells)
Immune cell specificity
Immune cell enhanced (memory B-cell)
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, Karpas-707, RPMI-8226)
Interaction
Interacts with PIN1.
Molecular function
DNA-binding
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