SPINK1

Serine protease inhibitor Kazal I (SPINK1) is a trypsin inhibitor encoded by the SPINK gene, which is secreted by pancreatic acinar cells into pancreatic juice, also known as pancreatic secretory trypsin inhibitor (tumor), and is associated trypsin inhibitor (TATI) or pancreatic secretory trypsin inhibitor (PSTI). Under normal conditions, SPINK1-trypsin complex secretes human pancreatic duct, and SPINK1 is isolated or degraded after reaching the small intestine. Trypsin inhibition Lifted. It is well known that the occurrence of pancreatitis is associated with abnormal activation of trypsinogen, so SPINK1 protein may play a first-line protection mechanism against activated trypsinogen during the pathogenesis of pancreatitis. It is currently known to be involved in the development of inflammation, cell proliferation and cancer, and genetic mutations can lead to chronic or hereditary pancreatitis. On the day of the day, SPINK1 expression levels are associated with the prognosis of many cancers.