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SPTB
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Anti-SPTB Products
- Human Anti-SPTB Recombinant Antibody (clone RG/26) (FAMAB-1261CQ)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: WB, IF, IHC
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- Human Anti-SPTB Antibody (clone RG/26), mRNA (FAMAB-1261CQ-mRNA)
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- Species Reactivity: Human
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Anti-SPTB Immunohistochemistry Kit (VS-0325-XY2166)
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- Species Reactivity: Human, Mouse, Rat
- Target: SPTB
- Application: IHC
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- Anti-Mouse SPTB Immunohistochemistry Kit (VS-0525-XY6882)
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- Species Reactivity: Human, Mouse, Rat
- Target: SPTB
- Application: IHC
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- Anti-Human SPTB Immunohistochemistry Kit (VS-0525-XY6881)
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- Species Reactivity: Human
- Target: SPTB
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, Inhibitory neurons, Horizontal cells, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (HEL, K-562, U-937)
Interaction
Composed of nonhomologous chains, alpha and beta, which aggregate to form dimers, tetramers, and higher polymers.
Molecular function
Actin capping, Actin-binding
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