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STK11

Anti-STK11 Products

Mouse Anti-STK11 Recombinant Antibody (clone 6G2) (MOB-2915z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IF, IHC
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Recombinant Mouse Anti-Human STK11 Antibody (clone 5I23) (MOB-1254MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, FC, ICC, IF, WB
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Mouse Anti-STK11 Recombinant Antibody (clone 4H12) (VS3-XY1474)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
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Anti-STK11 (clone W24V242) Recombinant Antibody Coupled Liposome (VS-1024-FY239) (VS-1024-FY239)
- Antibody Host: Mouse
- Antibody Reactivity: Human
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Anti-STK11 Immunohistochemistry Kit (VS-0325-XY2206)
- Species Reactivity: Human, Mouse, Rat
- Target: STK11
- Application: IHC
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Anti-Human STK11 Immunohistochemistry Kit (VS-0525-XY6973)
- Species Reactivity: Human
- Target: STK11
- Application: IHC
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For Research Use Only. Not For Clinical Use.

Background

The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.

Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Low cell line specificity

Interaction

Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with p53/TP53, SMAD4, STK11IP and WDR6. Interacts with NR4A1. Interacts with NISCH; this interaction may increase STK11 activity. Interacts with PTEN; leading to PTEN phosphorylation. Interacts with SIRT1; the interaction deacetylates STK11. Interacts with CDKN1A.

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase

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