Anti-STK11 (clone W24V242) Recombinant Antibody Coupled Liposome (VS-1024-FY239)
CAT#: VS-1024-FY239
Anti-STK11 antibody conjugated liposomes present a promising approach for targeted therapy in pancreatic cancer by enabling precise delivery of therapeutics directly to cancer cells expressing the STK11 protein. This targeted delivery can enhance the efficacy of chemotherapeutic agents while minimizing systemic toxicity, leading to improved patient outcomes. Additionally, these liposomes can be engineered to include diagnostic agents, facilitating real-time monitoring of treatment response and tumor progression. Overall, they represent a novel strategy that could significantly advance precision medicine in the management of pancreatic cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67481/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17254/40280_A_4_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17254/40280_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17254/40280_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17254/40280_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17254/40280_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17254/40280_A_4_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17254/40280_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118046-STK11/subcellular
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More Infomation
Specifications
- Potential Clinical Applications
- Pancreatic cancer
Product Composition
- Clone
- W24V242
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse monoclonal antibody that was crafted to selectively bind to the STK11 protein. This tailored approach ensures the antibody exhibits high specificity and strong binding capabilities, which is crucial for applications in both laboratory research and clinical settings that involve STK11. Targeting the STK11 protein can provide insights into its role in cellular processes and its association with certain diseases, paving the way for novel diagnostic and therapeutic strategies.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- STK11
- Introduction
- The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
- Alternative Names
- PJS; LKB1; hLKB1
- Full Name
- Serine/threonine kinase 11
- Gene ID
- 6794
- UniProt ID
- Q15831
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Nucleus; Cytoplasm; Membrane; Mitochondrion
- Post Translation Modifications
- Phosphorylated by ATM at Thr-363 following ionizing radiation (IR).
Phosphorylation at Ser-428 by RPS6KA1 and/or some PKA is required to inhibit cell growth.
Phosphorylation at Ser-428 is also required during neuronal polarization to mediate phosphorylation of BRSK1 and BRSK2 (By similarity).
Phosphorylation by PKC/PRKCZ at Ser-399 in isoform 2 promotes metformin (or peroxynitrite)-induced nuclear export of STK11 and activation of AMPK.
- Protein Refseq
- NP_000446.1; NP_001394184.1
- Function
- Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response.
Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK.
Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53.
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Datasheet
MSDS
COA
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| MOB-2915z | Mouse Anti-STK11 Recombinant Antibody (clone 6G2) | WB, ELISA, IF, IHC | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
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