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STK3
Loading...Anti-STK3 Products
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP
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- Anti-STK3 Immunohistochemistry Kit (VS-0325-XY2208)
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- Species Reactivity: Human, Mouse, Rat
- Target: STK3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Microglial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (A-431)
Interaction
Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation (By similarity). Interacts with and stabilizes SAV1 (PubMed:15688006, 16930133, 28087714). Interacts with RAF1, which prevents dimerization and phosphorylation. Interacts with RASSF1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of SAV1. Interacts with PKB/AKT1. Forms a tripartite complex with MOBKL1B and STK38. Interacts with RASSF2 (via SARAH domain). Interacts with DLG5 (via PDZ domain 3) (PubMed:28087714). Interacts with LATS1; this interaction is inhibited in the presence of DLG5 (PubMed:28087714). Interacts with MARK3 in the presence of DLG5 (PubMed:28087714).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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