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STUB1
Anti-STUB1 Recombinant Antibody Products
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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- Mouse Anti-STUB1 Recombinant Antibody (VS3-WK1219) (VS3-WK1219)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: WB
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- Recombinant Mouse Anti-STUB1 Antibody (VS-0923-FY234) (VS-0923-FY234)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- AbPlus™ Anti-STUB1 Magnetic Beads (VS-0724-YC1340) (VS-0724-YC1340)
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- Target: STUB1
- Target Species: Human
- Application: IP, Protein Purification
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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- Mouse Anti-NHP STUB1 Recombinant Antibody (clone 13I8) (VS-1024-XY494)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG2b
- Application: WB, IHC, FC
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- Anti-STUB1 Immunohistochemistry Kit (VS-0325-XY2218)
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- Species Reactivity: Human, Mouse, Rat
- Target: STUB1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (By similarity). Interacts with BAG2 (PubMed:16169850). Interacts with E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (PubMed:11557750). Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1 (PubMed:15215316). Interacts with MKKS (PubMed:18094050). Interacts with DNAAF4 (PubMed:19423554). Interacts (when monoubiquitinated) with ATXN3. Interacts with UBE2W. Interacts (via the U-box domain) with the UBE2V2-UBE2N heterodimer; the complex has a specific 'Lys-63'-linked polyubiquitination activity (By similarity). Interacts with DNAJB6 (PubMed:22366786). Interacts with FLCN (PubMed:27353360). Interacts with HSP90AA1 (PubMed:27353360, 24613385). Interacts with HSP90 (PubMed:11146632). Interacts with UBE2N and UBE2V1 (PubMed:16307917). Interacts (via TPR repeats) with the C-terminal domain of HSPA1A (PubMed:10330192). Interacts with the non-acetylated form of HSPA1A and HSPA1B (PubMed:27708256). Interacts (via TPR repeats) with the C-terminal domain of HSPA8 (PubMed:10330192, 11557750, 23990462, 27708256). Interacts with SMAD3 and HSP90AB1 (PubMed:24613385). Interacts with UBE4B (PubMed:17369820). Interacts with PRMT5 (PubMed:33376131).
Molecular function
Transferase
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