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TAPBPL
Loading...Anti-TAPBPL Products
- Recombinant Mouse Anti-Human TAPBPL Antibody (MOB-1540MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Mouse Anti-NHP TAPBPL Recombinant Antibody (clone OTI2A4) (VS-1024-XY499)
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- Species Reactivity: Dog, Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, IF
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- Anti-TAPBPL Immunohistochemistry Kit (VS-0525-XY7090)
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- Species Reactivity: Human
- Target: TAPBPL
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells, Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CAPAN-2, HDLM-2, Karpas-707, RPMI-8226)
Interaction
Interacts with peptide-free HLA-A*02-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange onto higher affinity peptides.
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