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THEMIS
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.
Predicted location
Intracellular
Single cell type specificity
Group enriched (T-cells, Excitatory neurons, Microglial cells)
Immune cell specificity
Group enriched (naive CD8 T-cell, memory CD8 T-cell, MAIT T-cell, memory CD4 T-cell, naive CD4 T-cell, gdT-cell)
Cell line specificity
Group enriched (HDLM-2, JURKAT, MOLT-4, RPMI-8226)
Interaction
Interacts with PLCG1, ITK, GRB2, and LAT.
Molecular function
Developmental protein
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