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TPMT
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Protein class
Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal tubular cells, Distal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer.
Molecular function
Methyltransferase, Transferase
More Types Infomation
- Recombinant Mouse Anti-Human TPMT Antibody (MOB-1815MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, ICC, IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IP, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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For Research Use Only. Not For Clinical Use.