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TRPM8
Loading...Anti-TRPM8 Products
- A*02:01/Human TRPM8 (GLMKYIGEV) MHC Pentamer (MHC-YF758)
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- Class: Class I
- Antigen: TRPM8
- Antigen Species: Human
- Peptide: GLMKYIGEV
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Anti-TRPM8 Immunohistochemistry Kit (VS-0525-XY7556)
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- Species Reactivity: Human
- Target: TRPM8
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane.
Protein class
FDA approved drug targets, Transporters, Voltage-gated ion channels
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Hepatocytes, Prostatic glandular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (GAMG, Karpas-707, RPTEC TERT1, SK-MEL-30, WM-115)
Interaction
Homotetramer (By similarity). Isoform 2 and isoform 3 interact with the C-terminus of isoform 1 in a thermosensitive manner with decreased interaction at 21 degrees Celsius compared to 37 degrees Celsius. Interacts (via N-terminus and C-terminus domains) with TCAF1; the interaction stimulates TRPM8 channel activity (PubMed:25559186). Interacts (via N-terminus and C-terminus domains) with TCAF2 isoform 2; the interaction inhibits TRPM8 channel activity (PubMed:25559186).
Molecular function
Ion channel
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