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TXNIP
Loading...Anti-TXNIP Products
- Rabbit Anti-TXNIP Recombinant Antibody (clone JM60-35) (MRO-1541-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Anti-Mouse TXNIP Immunohistochemistry Kit (VS-0525-XY7654)
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- Species Reactivity: Human, Mouse, Rat
- Target: TXNIP
- Application: IHC
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- Anti-TXNIP Immunohistochemistry Kit (VS-0525-XY7653)
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- Species Reactivity: Human
- Target: TXNIP
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a thioredoxin-binding protein that is a member. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, NK-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC TERT1, HSkMC, hTCEpi, hTERT-RPE1)
Interaction
Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.
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