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UPK2

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For Research Use Only. Not For Clinical Use.


This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
Protein class

Transporters

Predicted location

Membrane

Single cell type specificity

Group enriched (Cytotrophoblasts, Syncytiotrophoblasts, Urothelial cells, Club cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (MCF7, RT4)

Interaction

Interacts with uroplakin-1a (UPK1A).

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