Anti-UQCRB Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a frontrunner in the expanding field of mitochondrial biology, and we are pleased to present our premium line of anti-UQCRB recombinant antibodies. UQCRB is a small, low molecular weight, nuclear-encoded subunit of Complex III (cytochrome bc1 complex), and plays an important role in the structural assembly and function of the electron transport chain. Our top-quality antibodies will serve as an essential tool to study mitochondrial disease and evaluate the integrity of the respiratory supercomplexes.

UQCRB: A Small But Essential Complex III Subunit

Ubiquinol-Cytochrome c Reductase Binding Protein (UQCRB) is a small, nuclear-encoded Complex III subunit that serves as an anchor for the assembly of the respiratory chain by recruiting and stabilizing other subunits. UQCRB is also commonly referred to as the β subunit as it is located near the Q-cycle reaction center. Inappropriate assembly of UQCRB is associated with broad defects in mitochondrial function. The downstream manifestations of mitochondrial dysfunction can vary broadly, presenting in the form of many different metabolic and neurological disorders, a result of the systemic energy deficiency.

Alternative Names

Ubiquinol-Cytochrome C Reductase Binding Protein; Ubiquinol-Cytochrome C Reductase, Complex III Subunit VI; Ubiquinol-Cytochrome C Reductase Complex 14 KDa Protein; Cytochrome B-C1 Complex Subunit 7; Complex III Subunit VII; Complex III Subunit 7; UQBP; QP-C

Background

This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X.

Anti-UQCRB rAb Products

Our anti-UQCRB recombinant antibodies are generated with precision and optimized to give high performance and specificity. Each lot is carefully validated and shown to reliably detect UQCRB protein in mitochondrial fractions. These antibodies are optimized for use in Western Blot, where it is used to evaluate the integrity of supercomplex assembly, as well as IHC.

Table 1. Featured anti-UQCRB recombinant antibody products at Creative Biolabs.

Creative Quality Control

At Creative Biolabs, we hold our scientific standards to the highest level of rigor. The production of our anti-UQCRB recombinant antibodies is overseen by a robust quality assurance system and each lot is stringently tested for purity, specificity, and consistent performance in validated mitochondrial applications.

Customer Reviews

rAb Production

Creative Biolabs is dedicated to supporting the highly specialized field of mitochondrial research by leveraging cutting-edge production platforms to create precise and active tools. Our anti-UQCRB recombinant antibodies are expressed in highly optimized systems to ensure proper recognition of the native protein of interest for a specific and active tool.

Featured Anti-UQCRB Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-UQCRB recombinant antibody production.

Fig.4 Gram-scale anti-UQCRB recombinant antibody production.

rAb Modalities

Creative Biolabs is proud to be dedicated to enabling scientific breakthroughs by offering flexible antibody solutions. Our anti-UQCRB recombinant antibodies are available in a range of customizable modalities to fit your unique experimental needs.

Fig.5 Full-length anti-UQCRB recombinant antibody production and modalities.

Empower your mitochondrial research with the precision of Creative Biolabs' superior anti-UQCRB recombinant antibodies. Our portfolio is rigorously validated and consistently performs to deliver the tools you need to accurately investigate this critical Complex III subunit. Place your trust in our expertise and let us give your research a foundation you can rely on. Contact our specialists today.