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VEGFD

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus.
Protein class

Cancer-related genes, Plasma proteins, RAS pathway related proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Fibroblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HSkMC)

Interaction

Homodimer; non-covalent and antiparallel.

Molecular function

Developmental protein, Growth factor, Mitogen

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