Vimentin

Anti-Vimentin Products

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PE-A*02:02/Human VIM (RLRSSVPGV) MHC Tetramer (MHC-LC3782)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: RLRSSVPGV
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (RLRSSVPGV) MHC Tetramer (MHC-LC3783)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: RLRSSVPGV
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (ELNDRFANYI) MHC Tetramer (MHC-LC4137)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ELNDRFANYI
- Conjugate: PE
Compare

PE-A*02:06/Human VIM (RLRSSVPGV) MHC Tetramer (MHC-LC3784)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: RLRSSVPGV
- Conjugate: PE
Compare

PE-A*68:02/Human VIM (ELNDRFANYI) MHC Tetramer (MHC-LC4138)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ELNDRFANYI
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (RLRSSVPGV) MHC Tetramer (MHC-LC3785)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: RLRSSVPGV
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (ELNDRFANYI) MHC Tetramer (MHC-LC4139)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ELNDRFANYI
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (LQDSVDFSL) MHC Tetramer (MHC-LC3786)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: LQDSVDFSL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (ELNDRFANYI) MHC Tetramer (MHC-LC4140)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ELNDRFANYI
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (ALRPSTSRSL) MHC Tetramer (MHC-LC4124)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ALRPSTSRSL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (ALRPSTSRSL) MHC Tetramer (MHC-LC4125)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ALRPSTSRSL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (ALRPSTSRSL) MHC Tetramer (MHC-LC4126)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ALRPSTSRSL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (SLYASSPGGV) MHC Tetramer (MHC-LC4127)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: SLYASSPGGV
- Conjugate: PE
Compare

PE-A*68:02/Human VIM (SLYASSPGGV) MHC Tetramer (MHC-LC4128)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: SLYASSPGGV
- Conjugate: PE
Compare

PE-A*68:02/Human VIM (LQDSVDFSL) MHC Tetramer (MHC-LC3787)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: LQDSVDFSL
- Conjugate: PE
Compare

PE-A*02:06/Human VIM (LQDSVDFSL) MHC Tetramer (MHC-LC3788)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: LQDSVDFSL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (LQDSVDFSL) MHC Tetramer (MHC-LC3789)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: LQDSVDFSL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (FLEQQNKIL) MHC Tetramer (MHC-LC3790)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLEQQNKIL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (FLEQQNKIL) MHC Tetramer (MHC-LC3791)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLEQQNKIL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (FLEQQNKIL) MHC Tetramer (MHC-LC3792)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLEQQNKIL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (ILLAELEQL) MHC Tetramer (MHC-LC3793)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ILLAELEQL
- Conjugate: PE
Compare

PE-A*02:06/Human VIM (ILLAELEQL) MHC Tetramer (MHC-LC3794)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ILLAELEQL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (ILLAELEQL) MHC Tetramer (MHC-LC3795)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ILLAELEQL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (ILLAELEQL) MHC Tetramer (MHC-LC3796)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ILLAELEQL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (FLEQQNKILL) MHC Tetramer (MHC-LC4141)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLEQQNKILL
- Conjugate: PE
Compare

PE-A*02:06/Human VIM (FLEQQNKILL) MHC Tetramer (MHC-LC4142)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLEQQNKILL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (FLEQQNKILL) MHC Tetramer (MHC-LC4143)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLEQQNKILL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (FLEQQNKILL) MHC Tetramer (MHC-LC4144)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLEQQNKILL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (QLKGQGKSRL) MHC Tetramer (MHC-LC4145)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: QLKGQGKSRL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (QLKGQGKSRL) MHC Tetramer (MHC-LC4146)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: QLKGQGKSRL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (DLYEEEMREL) MHC Tetramer (MHC-LC4147)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: DLYEEEMREL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (DLYEEEMREL) MHC Tetramer (MHC-LC4148)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: DLYEEEMREL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (FLKKLHEEEI) MHC Tetramer (MHC-LC4149)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLKKLHEEEI
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (FLKKLHEEEI) MHC Tetramer (MHC-LC4150)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLKKLHEEEI
- Conjugate: PE
Compare

Human Anti-VIM Recombinant Antibody (HPAB-2717LY) (HPAB-2717LY)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FC, WB, Block, ELISA
Compare

PE-A*02:02/Human VIM (EMRELRRQV) MHC Tetramer (MHC-LC3797)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: EMRELRRQV
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (EMRELRRQV) MHC Tetramer (MHC-LC3798)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: EMRELRRQV
- Conjugate: PE
Compare

PE-A*68:02/Human VIM (ELRRQVDQL) MHC Tetramer (MHC-LC3799)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ELRRQVDQL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (ELRRQVDQL) MHC Tetramer (MHC-LC3800)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ELRRQVDQL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (ELRRQVDQL) MHC Tetramer (MHC-LC3801)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ELRRQVDQL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (ELRRQVDQL) MHC Tetramer (MHC-LC3802)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: ELRRQVDQL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (QLTNDKARV) MHC Tetramer (MHC-LC3803)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: QLTNDKARV
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (QLTNDKARV) MHC Tetramer (MHC-LC3804)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: QLTNDKARV
- Conjugate: PE
Compare

PE-A*02:06/Human VIM (QLTNDKARV) MHC Tetramer (MHC-LC3805)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: QLTNDKARV
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (QLTNDKARV) MHC Tetramer (MHC-LC3806)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: QLTNDKARV
- Conjugate: PE
Compare

PE-A*68:02/Human VIM (QLTNDKARV) MHC Tetramer (MHC-LC3807)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: QLTNDKARV
- Conjugate: PE
Compare

PE-A*68:02/Human VIM (NLAEDIMRL) MHC Tetramer (MHC-LC3808)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: NLAEDIMRL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (NLAEDIMRL) MHC Tetramer (MHC-LC3809)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: NLAEDIMRL
- Conjugate: PE
Compare

PE-A*02:06/Human VIM (NLAEDIMRL) MHC Tetramer (MHC-LC3810)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: NLAEDIMRL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (NLAEDIMRL) MHC Tetramer (MHC-LC3811)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: NLAEDIMRL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (NLAEDIMRL) MHC Tetramer (MHC-LC3812)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: NLAEDIMRL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (TLQSFRQDV) MHC Tetramer (MHC-LC3813)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: TLQSFRQDV
- Conjugate: PE
Compare

PE-A*68:02/Human VIM (TLQSFRQDV) MHC Tetramer (MHC-LC3814)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: TLQSFRQDV
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (TLQSFRQDV) MHC Tetramer (MHC-LC3815)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: TLQSFRQDV
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (TLQSFRQDV) MHC Tetramer (MHC-LC3816)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: TLQSFRQDV
- Conjugate: PE
Compare

DRB1*04:01/Human cit vimentin (GVYAT[cit]SSAV[cit]L[cit]SSVPGVR) MHC Monomer (MHC-YF038)
- Class: Class II
- Antigen: cit vimentin
- Antigen Species: Human
- Peptide: GVYAT[cit]SSAV[cit]L[cit]SSVPGVR
- Conjugate: Biotin
Compare

Human Anti-VIM Antibody, mRNA (TAB-662CL-mRNA)
- Species Reactivity: Human
Compare

Mouse Anti-VIM Recombinant Antibody (ZG-0499F) (ZG-0499F)
- Species Reactivity: Human, Monkey
- Type: Mouse IgG
- Application: WB, IHC, ELISA
Compare

Mouse Anti-VIM Recombinant Antibody (ZG-0500F) (ZG-0500F)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
Compare

PE-A*02:02/Human VIM (FLKKLHEEEI) MHC Tetramer (MHC-LC4151)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: FLKKLHEEEI
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (KLHEEEIQEL) MHC Tetramer (MHC-LC4152)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: KLHEEEIQEL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (DLERKVESL) MHC Tetramer (MHC-LC3817)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: DLERKVESL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (KLHEEEIQEL) MHC Tetramer (MHC-LC4153)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: KLHEEEIQEL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (KLHEEEIQEL) MHC Tetramer (MHC-LC4154)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: KLHEEEIQEL
- Conjugate: PE
Compare

PE-A*02:06/Human VIM (DLERKVESL) MHC Tetramer (MHC-LC3818)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: DLERKVESL
- Conjugate: PE
Compare

PE-A*02:06/Human VIM (KLHEEEIQEL) MHC Tetramer (MHC-LC4155)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: KLHEEEIQEL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (DLERKVESL) MHC Tetramer (MHC-LC3819)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: DLERKVESL
- Conjugate: PE
Compare

PE-A*02:01/Human VIM (NMKEEMARHL) MHC Tetramer (MHC-LC4156)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: NMKEEMARHL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (DLERKVESL) MHC Tetramer (MHC-LC3820)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: DLERKVESL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (NMKEEMARHL) MHC Tetramer (MHC-LC4157)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: NMKEEMARHL
- Conjugate: PE
Compare

BV421-DRB1*04:01/Human VIM (GVYATRSSAVRLR) MHC Tetramer (MHC-LC1813)
- Class: Class II
- Antigen: VIM
- Antigen Species: Human
- Peptide: GVYATRSSAVRLR
- Conjugate: BV421
Compare

PE-A*02:02/Human VIM (SLQEEIAFL) MHC Tetramer (MHC-LC3821)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: SLQEEIAFL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (NMKEEMARHL) MHC Tetramer (MHC-LC4158)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: NMKEEMARHL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (SLQEEIAFL) MHC Tetramer (MHC-LC3822)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: SLQEEIAFL
- Conjugate: PE
Compare

PE-A*02:02/Human VIM (LLNVKMALDI) MHC Tetramer (MHC-LC4159)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: LLNVKMALDI
- Conjugate: PE
Compare

Afuco™ Anti-Human VIM ADCC Recombinant Antibody, ADCC Enhanced (AFC-636CL)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
Compare

Mouse Anti-VIM Recombinant Antibody (clone 28A3) (MOB-1153z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IHC, IP
Compare

Recombinant Mouse anti-Human VIM Monoclonal antibody (ZU44) (MOB-2217CT)
- Species Reactivity: Human
- Application: ICC, WB
Compare

PE-DRB*01:01/Human VIM (SAVRLRSSVPGVR) MHC Tetramer (MHC-LC1805)
- Class: Class II
- Antigen: VIM
- Antigen Species: Human
- Peptide: SAVRLRSSVPGVR
- Conjugate: PE
Compare

PE-DRB1*04:01/Human VIM (GVYATRSSAVRLR) MHC Tetramer (MHC-LC1811)
- Class: Class II
- Antigen: VIM
- Antigen Species: Human
- Peptide: GVYATRSSAVRLR
- Conjugate: PE
Compare

APC-DRB*01:01/Human VIM (SAVRLRSSVPGVR) MHC Tetramer (MHC-LC1806)
- Class: Class II
- Antigen: VIM
- Antigen Species: Human
- Peptide: SAVRLRSSVPGVR
- Conjugate: APC
Compare

APC-DRB1*04:01/Human VIM (GVYATRSSAVRLR) MHC Tetramer (MHC-LC1812)
- Class: Class II
- Antigen: VIM
- Antigen Species: Human
- Peptide: GVYATRSSAVRLR
- Conjugate: APC
Compare

BV421-DRB*01:01/Human VIM (SAVRLRSSVPGVR) MHC Tetramer (MHC-LC1807)
- Class: Class II
- Antigen: VIM
- Antigen Species: Human
- Peptide: SAVRLRSSVPGVR
- Conjugate: BV421
Compare

PE-A*02:06/Human VIM (SLQEEIAFL) MHC Tetramer (MHC-LC3823)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: SLQEEIAFL
- Conjugate: PE
Compare

PE-A*02:03/Human VIM (LLNVKMALDI) MHC Tetramer (MHC-LC4160)
- Class: Class I
- Antigen: VIM
- Antigen Species: Human
- Peptide: LLNVKMALDI
- Conjugate: PE
Compare

Mouse Anti-VIM Recombinant Antibody; scFv Fragment (HPAB-0350-YJ-S(P)) (HPAB-0350-YJ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, IP, ICC, IHC, FC, IF
Compare

Anti-Human VIM Recombinant Antibody (TAB-662CL)
- Species Reactivity: Human
- Type: Antibody
Compare

Anti-Human VIM Recombinant Antibody (HoAKs-1) (TAB-353CQ)
- Species Reactivity: Human
- Application: ELISA
Compare

Anti-Human VIM Recombinant Antibody (2F6-1) (TAB-354CQ)
- Species Reactivity: Human
- Application: IF
Compare

Anti-Human VIM Recombinant Antibody (3F9-1) (TAB-355CQ)
- Species Reactivity: Human
- Application: IF
Compare

Anti-Human VIM Recombinant Antibody scFv Fragment (HoAKs-1) (TAB-353CQ-S(P))
- Species Reactivity: Human
- Application: ELISA, WB
Compare

Anti-Human VIM Recombinant Antibody scFv Fragment (2F6-1) (TAB-354CQ-S(P))
- Species Reactivity: Human
- Application: ELISA, WB
Compare

Anti-Human VIM Recombinant Antibody scFv Fragment (3F9-1) (TAB-355CQ-S(P))
- Species Reactivity: Human
- Application: ELISA, WB
Compare

Anti-Human VIM Recombinant Antibody Fab Fragment (HoAKs-1) (TAB-353CQ-F(E))
- Species Reactivity: Human
- Application: ELISA, WB
Compare

Anti-Human VIM Recombinant Antibody Fab Fragment (2F6-1) (TAB-354CQ-F(E))
- Species Reactivity: Human
- Application: ELISA, WB
Compare

Anti-Human VIM Recombinant Antibody Fab Fragment (3F9-1) (TAB-355CQ-F(E))
- Species Reactivity: Human
- Application: ELISA, WB
Compare

Mouse Anti-VIM Recombinant Antibody; scFv Fragment (HPAB-0349-YJ-S(P)) (HPAB-0349-YJ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, IP, ICC, IHC, FC, IF
Compare

Human Anti-VIM Recombinant Antibody Fab Fragment (HPAB-2717LY-F(E)) (HPAB-2717LY-F(E))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC, WB, Block, ELISA
Compare

Chicken Anti-VIM Polyclonal IgY (BRD-0741MZ)
- Species Reactivity: Human, Rat, Mouse
- Type: Chicken antibody
- Application: ICC, IF, IHC, WB
Compare

Rabbit Anti-Vimentin Recombinant Antibody (clone SI583DS) (MOR-4486)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
Compare

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For Research Use Only. Not For Clinical Use.

Background

Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions. It is found that vimentin control the transport of low-density lipoprotein. It has been used as a sarcoma tumor marker to identify mesenchyme.

This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]

This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.