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WWOX
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Astrocytes, Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons, Microglial cells, Excitatory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (MCF7)
Interaction
Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207.
Molecular function
Oxidoreductase
More Types Infomation
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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For Research Use Only. Not For Clinical Use.