Rabbit Anti-WWOX Recombinant Antibody (clone R02-0E3) (CAT#: VS3-FY2102)

• Immunogen
• Recombinant human WWOX protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Mouse WWOX

• Species Reactivity
• Human, Mouse

• Clone
• R02-0E3

• Applications
• Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 47 kDa, while the observed molecular weight stands at 47 kDa.

• Related Disease
• Cancer

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunoprecipitation: 1/20

• Alternative Names
• WW Domain Containing Oxidoreductase; Short Chain Dehydrogenase/Reductase Family 41C Member 1; WW Domain-Containing Oxidoreductase; Fragile Site FRA16D Oxidoreductase; SDR41C1; WOX1; FOR; Short Chain Dehydrogenase/Reductase Family 41C, Member 1; WW Domain-Containing Protein WWOX

• Gene ID
• 51741

• UniProt ID
• Q9NZC7

• Sequence Similarities
• Belongs to the short-chain dehydrogenases/reductases (SDR) family.

• Cellular Localization
• Cytoplasm, Golgi apparatus, Lysosome, Mitochondrion, Nucleus

• Post Translation Modifications
• Phosphorylated upon genotoxic stress.
  Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8.
  May also regulate proapoptotic activity.
  Phosphorylation by TNK2 is associated with polyubiquitination and degradation.
  Ubiquitinated when phosphorylated by TNK2, leading to its degradation. (Q9NZC7-WWOX_HUMAN)
  Ubiquitination at Lys100 and Lys274 (NX_Q9NZC7 [NX_Q9NZC7-1])
  Modification sites at PhosphoSitePlus (Q9NZC7)

• Protein Refseq
• NP_001278926.1; NP_057457.1; NP_570607.1

• Function
• May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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