ZHX2

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]GeneCards Summary for ZHX2 Gene ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Diseases associated with ZHX2 include Smallpox and Cryptococcosis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is ZHX1.Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.