Plasma proteins, Transcription factors
Intracellular
Group enriched (Astrocytes, Oligodendrocyte precursor cells, Oligodendrocytes, Microglial cells)
Low immune cell specificity
Cell line enhanced (Daudi, REH, U-698)
Homodimer (via homeobox domain) (PubMed:12741956, PubMed:14659886). Heterodimer with ZHX1 (via homeobox domain 1) (PubMed:12741956). Heterodimer with ZHX3 (via homeobox domain 1) (PubMed:12741956, PubMed:14659886). Heterodimerization with ZHX1 is not necessary for repressor activity (PubMed:12741956). Interacts (via homeobox domain) with NFYA (via N-terminus) (PubMed:12741956). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity).
DNA-binding, Repressor
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For Research Use Only. Not For Clinical Use.