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IL36RN

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For Research Use Only. Not For Clinical Use.


Background

The IL36RN gene provides instructions for making a protein called interleukin 36 receptor antagonist (IL-36Ra). This protein is primarily found in the skin.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts, Extravillous trophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BEWO, GAMG, U-87 MG)

Interaction

Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.

Molecular function

Cytokine

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