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For Research Use Only. Not For Clinical Use.


Background

LACZ, or Hypoxanthine-guanine-xanthine phosphoribosyltransferase, despite the common abbreviation for beta-galactosidase (lacZ gene), this entry describes a purine salvage enzyme. This H/G/XPRT catalyzes the transfer of phosphoribosyl groups from PRPP to hypoxanthine, guanine, or xanthine, forming IMP, or XMP, respectively. This salvages purine bases for nucleotide synthesis.
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