Anti-TM4SF1 (clone v1.10)-mc-LP2 ADC (CAT#: ADC-074LZY)

• Antibody Overview
• Humanized Anti-Human TM4SF1 mAb, v1.10

• Clone
• v110

• Antibody Conjugation
• ADCs were prepared by partial reduction of the antibodies with tris(2-carboxyethyl)phosphine followed by
  coupling to maleimidocapronic-auristatin (mc3377) (33). Excess of N-ethylmaleimide and L-Cys were added in
  sequence to cap the unreacted thi

• Linker
• mc(maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linker
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation

• Drug
• LP2 (chemical name mc-3377)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

• Alternative Names
• TM4SF1; transmembrane 4 L six family member 1; L6; H-L6; M3S1; TAAL6; transmembrane 4 L6 family member 1; tumor-associated antigen L6; transmembrane 4 superfamily member 1; membrane component chromosome 3 surface marker 1; membrane component, chromosome 3, surface marker 1;

• Gene ID
• 4071

• UniProt ID
• P30408

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