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TM4SF1
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Basal prostatic cells, Urothelial cells, Prostatic glandular cells, Pancreatic endocrine cells, Endothelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (CAPAN-2, hTERT-RPE1, HUVEC TERT2, LHCN-M2, OE19)
Interaction
Present in high molecular weight complexes in tumor cells. Interacts with SDCBP2 (PubMed:11102519).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, ICC, IHC
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- Target: TAL6
- Species Reactivity: Human
- Cytokine 1: PF4
- Host: Chimeric (Human-Mouse)
- Cytokine 1 Species: Human
- Molecule Class: scFv-PF4
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- Target: TAL6
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: scFv-IL2
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC
-
- Target: TAL6
- Species Reactivity: Human
- Cytokine 1: FasL
- Host: Chimeric (Human-Mouse)
- Cytokine 1 Species: Human
- Molecule Class: scFv-FasL
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC
- Anti-TM4SF1 (clone 2A7A)-mc-LP2 ADC (ADC-075LZY)
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- Target: TM4SF1
- Linker: mc(maleimidocaproyl)
- Drug: LP2 (chemical name mc-3377)
- Anti-TM4SF1 (clone v1.10)-mc-LP2 ADC (ADC-074LZY)
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- Target: TM4SF1
- Linker: mc(maleimidocaproyl)
- Drug: LP2 (chemical name mc-3377)
-
- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, IHC
- Human Anti-TM4SF1 Recombinant Antibody (VS-0723-WK10) (VS-0723-WK10)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: FC
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For Research Use Only. Not For Clinical Use.