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  3. 10-FnIII scaffold protein anti-Human Abelson (Abl) kinase SH2 domain

10-FnIII anti-ABL1 (SFN-L001)

The tenth fibronectin type III domain (10Fn3) that bound Abelson (Abl) kinase SH2 domain was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=7 nM) for Abelson (Abl) kinase SH2 domain as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      
Datasheet
Specifications
Scaffold Name
10-FnIII
Origin
Fibronectin
Core Structure
β-sandwich of 7 β-strands
Variable Regions
2 Loops
Target
Abelson (Abl) kinase SH2 domain
Species Reactivity
Human
Expression Host
BL21 (DE3) cells
Affinity Constant
7 nM
Applications
ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
Alternative Names
Fibronectin; 10-FnIII; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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