10-FnIII scaffold protein anti-Human Abelson (Abl) kinase SH2 domain (CAT#: SFN-L001)

The tenth fibronectin type III domain (10Fn3) that bound Abelson (Abl) kinase SH2 domain was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=7 nM) for Abelson (Abl) kinase SH2 domain as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Specific Inquiry
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  • Conjugation:

  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Scaffold Name
  • 10-FnIII
  • Origin
  • Fibronectin
  • Core Structure
  • β-sandwich of 7 β-strands
  • Variable Regions
  • 2 Loops
  • Target
  • Abelson (Abl) kinase SH2 domain
  • Species Reactivity
  • Human
  • Expression Host
  • BL21 (DE3) cells
  • Affinity Constant
  • 7 nM
  • Applications
  • ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

  • Alternative Names
  • Fibronectin; 10-FnIII; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl

Related Resources

  • Related Signaling Pathways

Downloads

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