Anti-FcRL5 (10A8)-SPDB-DM4 ADC (CAT#: ADC-117LCT)

• Clone
• 10A8

• Linker
• SPDB

• Linker Class/Description
• Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)

• Drug Class/Description
• Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

• Introduction
• This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

• Alternative Names
• FCRL5; Fc receptor-like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820; Fc receptor-like protein 5; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2);

• Gene ID
• 83416

• UniProt ID
• Q96RD9

• ADC-163CL
• Anti-FcRH5 (clone 10A8)-SMCC-DM1 ADC

• ADC-166CL
• Anti-FcRH5 (clone 10A8)-vc-MMAE ADC

• ADC-115LCT
• Anti-FcRL5 (10A8)-MC-vcPAB-MMAE ADC

• ADC-167CL
• Anti-FcRH5 (clone 10A8)-vc-MMAE ADC

• ADC-169CL
• Anti-FcRH5 (clone 10A8)-MC-vc-PAB-MMAE ADC

• ADC-170CL
• Anti-FcRH5 (clone 10A8)-MC-vc-PAB-MMAE ADC

• ADC-171CL
• Anti-FcRH5 (clone 10A8)-MC-vc-PAB-MMAE ADC

• ADC-172CL
• Anti-FcRH5 (clone 10A8)-SPDB-DM4 ADC

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