Anti-FcRH5 (clone 10A8)-MC-vc-PAB-MMAE ADC (CAT#: ADC-169CL)

• Antibody Overview
• Anti-FcRH5(10A8)-HC(Al 18C)

• Clone
• 10A8

• Linker
• MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

• Alternative Names
• FCRL5; Fc receptor-like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820; Fc receptor-like protein 5; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2);

• Gene ID
• 83416

• UniProt ID
• Q96RD9

• ADC-163CL
• Anti-FcRH5 (clone 10A8)-SMCC-DM1 ADC

• ADC-166CL
• Anti-FcRH5 (clone 10A8)-vc-MMAE ADC

• ADC-115LCT
• Anti-FcRL5 (10A8)-MC-vcPAB-MMAE ADC

• ADC-167CL
• Anti-FcRH5 (clone 10A8)-vc-MMAE ADC

• ADC-117LCT
• Anti-FcRL5 (10A8)-SPDB-DM4 ADC

• ADC-170CL
• Anti-FcRH5 (clone 10A8)-MC-vc-PAB-MMAE ADC

• ADC-171CL
• Anti-FcRH5 (clone 10A8)-MC-vc-PAB-MMAE ADC

• ADC-172CL
• Anti-FcRH5 (clone 10A8)-SPDB-DM4 ADC

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