Anti-FcRH5 (clone 10A8)-SPDB-DM4 ADC
CAT#: ADC-172CL
This ADC product is composed of an anti-FcRH5 antibody (clone 10A8) conjugated via SPDB linker to DM4(Hu anti-FcRH5 10A8-SPDB-DM4). It has demonstrated a response in treatment by a MOA (Mechanism of Action) as microtubule inhibitor.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143297-FCRL5
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Specifications
- Antibody Overview
- Hu Anti-FcRH5 10A8
- Clone
- 10A8
- Linker
- SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
- Linker Class/Description
- Class: Chemically cleavable linkers-Disulfide Linkers
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
- Alternative Names
- FCRL5; Fc receptor-like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820; Fc receptor-like protein 5; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2);
- Gene ID
- 83416
- UniProt ID
- Q96RD9
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COA
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See other products for "Clone 10A8"
- CAT
- Product Name
See other products for "FCRL5"
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| CAT | Product Name | Application | Type |
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| HPAB-0180CQ | Human Anti-FCRL5 Recombinant Antibody (clone 9D12) | ELISA, FC | Human IgG1, κ |
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| HPAB-0180CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody (clone 9D12); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0181CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody (clone 8A1); scFv Fragment | ELISA, FC | Human scFv |
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|---|---|---|---|
| VS-0425-YC616 | Recombinant Anti-FCRL5 Vesicular Antibody, EV Displayed (VS-0425-YC616) | ELISA, FC, Cell-uptake |
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