APC-A*01:01/Human MAGEA3 (ESDPIVAQY) MHC Tetramer
CAT#: MHC-LC927
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of MAGEA3-derived peptide of ESDPIVAQY covering 168-176 and A*01:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (GAMG, K-562, OE19, PC-3, SH-SY5Y, SK-BR-3, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000221867-MAGEA3
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Specifications
- Allele
- A*01:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- MAGE-A3
- Antigen Species
- Human
- Peptide
- ESDPIVAQY
- Range
- 168-176
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
- Alternative Names
- MAGEA3; MAGE family member A3; HIP8; HYPD; CT1.3; MAGE3; MAGEA6
- Gene ID
- 4102
- UniProt ID
- P43357
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Critical for Cancer Immunology
Utilizing this tetramer, we've gained deep insights into hMAGEA3-specific T cell populations. Such specificity is invaluable in our endeavors to develop targeted immunotherapies, providing reliable data to guide vaccine and T cell therapy design.
Trustworthy for Accurate Immune Mapping
Its high specificity allows for precise mapping of immune responses, which is crucial for understanding how tumor antigens like hMAGEA3 are recognized by the immune system, leading to better therapeutic interventions.
Q&As
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What is the primary application of the APC-A01:01/hMAGEA3 168-176 MHC Tetramer?
A: This MHC tetramer is primarily used in flow cytometry to detect antigen-specific T cells. It is designed to recognize T cells specific for the hMAGEA3 168-176 peptide, assisting in the study of immune responses, especially in cancer immunology.
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Why is the hMAGEA3 antigen significant in research?
A: hMAGEA3 is a cancer/testis antigen expressed in various tumors but not in normal tissues, except for testes. This makes it an excellent target for cancer immunotherapy research, aiding the development of vaccines and monitoring T cell responses in immunotherapy trials.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2790z | Mouse Anti-MAGEA3 Recombinant Antibody (clone 6B5) | WB, IHC | Mouse IgG2a |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0715CL-S(P) | Anti-Human MAGEA3 Recombinant Antibody scFv Fragment (32H2) | ELISA | Human antibody |
| TAB-0715CL-F(E) | Anti-Human MAGEA3 Recombinant Antibody Fab Fragment (32H2) | ELISA | Human antibody |
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| TAB-0717CL-F(E) | Anti-Human MAGEA3 Recombinant Antibody Fab Fragment (122G3) | ELISA | Human antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0183-LSX-S(P) | Human Anti-MAGEA3 Recombinant Antibody (clone 21B4); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-0184-LSX-S(P) | Human Anti-MAGEA3 Recombinant Antibody (clone M3H67); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-0185-LSX-S(P) | Human Anti-MAGEA3 Recombinant Antibody (clone 31H10); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-M0276-YC-S(P) | Human Anti-MAGEA3 Recombinant Antibody (clone M/YC-24); scFv Fragment | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0183-LSX-F(E) | Human Anti-MAGEA3 Recombinant Antibody (clone 21B4); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0184-LSX-F(E) | Human Anti-MAGEA3 Recombinant Antibody (clone M3H67); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0185-LSX-F(E) | Human Anti-MAGEA3 Recombinant Antibody (clone 31H10); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-M0276-YC-F(E) | Human Anti-MAGEA3 Recombinant Antibody (clone M/YC-24); Fab Fragment | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| VS-0525-XY4173 | Anti-Mouse MAGEA3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4172 | Anti-Human MAGEA3 Immunohistochemistry Kit | IHC |
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