APC-A*02:01/Human IAPP (KLQVFLIVL) MHC Tetramer (CAT#: MHC-LC672)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of IAPP-derived peptide of KLQVFLIVL sequence covering 5-13 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53194/1947_F12_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53194/1947_F12_2_selected.jpg
Figure 2 High expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53194/129355_A_1_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53194/129355_A_1_3_val_selected.jpg
Figure 3 Low expression in colon
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53194/129355_A_9_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53194/129355_A_9_3_val_selected.jpg
Figure 4 Pancreas
(Pancreatic endocrine cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53194/129355_A_1_3.jpg
(Pancreatic endocrine cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53194/129355_A_1_3.jpg
Figure 5 RNA cell line category: Cell line enhanced (U-2 OS)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121351-IAPP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121351-IAPP
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- IAPP
- Antigen Species
- Human
- Peptide
- KLQVFLIVL
- Range
- 5-13
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity.
- Alternative Names
- IAPP; islet amyloid polypeptide; DAP; IAP
- Gene ID
- 3375
- UniProt ID
- P10997
Downloads
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IgG Antibody Products
Human Antibody Products
Mouse Antibody Products
MHC Tetramer Products for Other Applications
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2254z | Mouse Anti-IAPP Recombinant Antibody (clone 35D9) | ICC, IF, IHC | Mouse IgG1 |
| HPAB-0295-YC | Human Anti-IAPP Recombinant Antibody (clone HlLl) | FuncS | Humanized IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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