APC-B*07:02/Human EIF4G1 (AARPATSTL) MHC Tetramer (CAT#: MHC-LC2091)

• Allele
• B*07:02

• Class
• Class I

• MHC Species
• Human

• Antigen
• EIF4G1

• Antigen Species
• Human

• Peptide
• AARPATSTL

• Range
• 1113-1121

• Conjugate
• APC

• Application
• FCM

• Antigen Introduction
• The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

• Alternative Names
• EIF4G1; Eukaryotic translation initiation factor 4 gamma 1; P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1

• Gene ID
• 1981

• UniProt ID
• Q04637

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