EIF4G1

Tetramer Products AbPlus Formats

Anti-EIF4G1 Recombinant Antibody Products

Recombinant Mouse Anti-Human EIF4G1 Antibody (MOB-1377MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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PE-B*07:02/Human EIF4G1 (AARPATSTL) MHC Tetramer (MHC-LC2090)
- Class: Class I
- Antigen: EIF4G1
- Antigen Species: Human
- Peptide: AARPATSTL
- Conjugate: PE
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APC-B*07:02/Human EIF4G1 (AARPATSTL) MHC Tetramer (MHC-LC2091)
- Class: Class I
- Antigen: EIF4G1
- Antigen Species: Human
- Peptide: AARPATSTL
- Conjugate: APC
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Anti-EIF4G1 Immunohistochemistry Kit (VS-0325-XY754)
- Species Reactivity: Human
- Target: EIF4G1
- Application: IHC
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with RBM4. Interacts with HNRNPD/AUF1; the interaction requires RNA. Directly interacts with EIF4G1 in an RNA-independent manner (PubMed:22872150). (Microbial infection) Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. (Microbial infection) Interacts with human adenovirus 5 protein 100K; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs.

Molecular function

Initiation factor, RNA-binding, Translational shunt

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