APC-B44/Human CYP2D6 (SEIDLILGY) MHC Tetramer (CAT#: MHC-LC3440)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CYP2D6 of peptide SEIDLILGY and B44 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Allele
  • B44
  • Class
  • Class I
  • Antigen
  • CYP2D6
  • Antigen Species
  • Human
  • Peptide
  • SEIDLILGY
  • Conjugate
  • APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • CYP2D6; cytochrome P450 family 2 subfamily D member 6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1335z Mouse Anti-CYP2D6 Recombinant Antibody (clone 26F1) ELISA, WB Mouse IgG2b
MRO-0430-CN Rabbit Anti-CYP2D6 Recombinant Antibody (clone JM44-23) WB, IF, IHC, FC Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC3435 PE-B44/Human CYP2D6 (SEIDLILGY) MHC Tetramer FCM

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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