APC-B44/Human CYP2D6 (SEIDLILGY) MHC Tetramer
CAT#: MHC-LC3440
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CYP2D6 of peptide SEIDLILGY and B44 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45223/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45223/575_C6_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45223/568_C6_1_blue_red_green.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45223/170068_A_7_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000100197-CYP2D6
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Specifications
- Allele
- B44
- Class
- Class I
- MHC Species
- Human
- Antigen
- CYP2D6
- Antigen Species
- Human
- Peptide
- SEIDLILGY
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- CYP2D6; cytochrome P450 family 2 subfamily D member 6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1
- Gene ID
- 1565
- UniProt ID
- P10635
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COA
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| MOB-1335z | Mouse Anti-CYP2D6 Recombinant Antibody (clone 26F1) | ELISA, WB | Mouse IgG2b |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3435 | PE-B44/Human CYP2D6 (SEIDLILGY) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
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| VS-0325-XY607 | Anti-CYP2D6 Immunohistochemistry Kit | IHC | |
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