Anti-CYP2D6 Products

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For Research Use Only. Not For Clinical Use.

Pioneering neuroscience and psychiatry research is only as good as the tools you use to make breakthroughs. Creative Biolabs provides you with the most selective anti-CYP2D6 recombinant antibodies for functional and quantitative investigations. Known as the most polymorphic and clinically significant drug-metabolizing enzyme, CYP2D6 plays a major role in patients' response to psychotropics and opioids. CYP2D6's dramatic influence on pharmacogenomics and therapeutic dosing of CNS medications makes our high-quality antibodies a crucial tool for your research.

CYP2D6: The Most Polymorphic CNS Drug Metabolizer

Cytochrome P450 2D6 (CYP2D6) is a monooxygenase enzyme predominantly expressed in the liver. While it is only involved in the metabolism of a small fraction of all drugs, it metabolizes a vast number of different compounds, with up to 25% of all commonly used drugs being substrates of this enzyme, especially antidepressants, antipsychotics, beta-blockers, and opioids such as codeine1. CYP2D6 exhibits a high degree of polymorphism. Patients are categorized into four different metabolic phenotypes based on their CYP2D6 function, which include ultrarapid, extensive, intermediate, and poor metabolizers, causing either therapeutic failure or life-threatening toxicity, such as codeine overdose in ultrarapid metabolizers.

Alternative Names

CYP2D6; Xenobiotic Monooxygenase; EC 1.14.14.1; Cytochrome P450-DB1; CYP2D8P2; CPD6; CYP2D; Flavoprotein-Linked Monooxygenase; Cytochrome P450, Subfamily II (Debrisoquine, Sparteine, Etc., -Metabolising), Polypeptide 7 Pseudogene 2; CYP2DL1; CYPIID6; Micr

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-CYP2D6 rAb Products

Creative Biolabs' anti-CYP2D6 recombinant antibodies have been engineered for high specificity against the target antigen. They are meticulously validated and rigorously tested to ensure they can reliably detect the CYP2D6 enzyme. Optimized for use in applications such as Western Blot of liver microsomes and IHC, our CYP2D6 rAbs will provide the robustness and specificity needed for neuropharmacology and pharmacogenomics research.

Table 1. Featured anti-CYP2D6 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is proud to be in the business of making groundbreaking science possible. Using our proprietary, state-of-the-art rAb production platforms, we can deliver you high-quality tools with complete customization to fit the needs of an emerging and important field like neuropharmacology. Creative Biolabs' anti-CYP2D6 recombinant antibodies are expressed in carefully optimized systems to ensure the highest specificity and that they will correctly recognize the native form of the enzyme you're working with, providing you with a highly specific and active research tool.

Featured Anti-CYP2D6 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CYP2D6 recombinant antibody production.

Fig.2 Gram-scale anti-CYP2D6 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to fueling scientific progress by providing you with the most advanced and flexible antibody solutions possible. Our anti-CYP2D6 recombinant antibodies are available in many different customizable formats to meet all of your experimental needs.

Fig.3 Full-length anti-CYP2D6 recombinant antibody production and modalities.

The right antibody can make all the difference when dissecting mechanisms of drug metabolism in neuropharmacology. Give your research on CYP2D6, the most polymorphic and clinically significant drug metabolizing enzyme, the specificity and validation you need with Creative Biolabs' superior anti-CYP2D6 recombinant antibodies. Our portfolio of high-quality products and rigorous validation will help give you the robust research foundation you need. Contact one of our experts today.