APC-HLA-DRB1*11:01/Influenza A virus HA (PKYVKQNTLKLAT) MHC Tetramer
CAT#: MHC-LC583
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Influenza-derived peptide of PKYVKQNTLKLAT sequence covering 306-318 and HLA-DRB1*11:01 molecule. The pMHC tetramer recognizes human CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*11:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Influenza A virus HA
- Antigen Species
- Influenza A virus
- Peptide
- PKYVKQNTLKLAT
- Range
- 306-318
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- Influenza A virus causes influenza in birds and some mammals, and is the only species of influenza virus A. Influenza virus A is a genus of the Orthomyxoviridae family of viruses. Strains of all subtypes of influenza A virus have been isolated from wild birds, although disease is uncommon. Some isolates of influenza A virus cause severe disease both in domestic poultry and, rarely, in humans. Occasionally, viruses are transmitted from wild aquatic birds to domestic poultry, and this may cause an outbreak or give rise to human influenza pandemics.
- Alternative Names
- Influenza A virus hemagglutinin; Influenza A virus HA
- Gene ID
- 3654620
- UniProt ID
- Q9Q0U6
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Enhances Multicolor Flow Cytometry Analyses
Compatible with multiple fluorescent labels, the tetramer expands our ability to perform comprehensive cell profiling, giving us a broader understanding of the immune cell landscape and functional diversity in response to influenza.
Instrumental in Understanding Viral Immunity
Its targeted application provides deep insights into the specific immune responses against the influenza virus, furthering our knowledge of viral immunity and inspiring new directions in antiviral research.
Q&As
-
Why is the HA 306-318 epitope significant in influenza research?
A: The hemagglutinin (HA) protein of the Influenza A virus is a key target for immune responses. Investigating T cell specificity to the HA 306-318 epitope aids in understanding immune protection and guiding vaccine development against influenza.
-
What are the recommended storage conditions to maintain the tetramer's effectiveness?
A: Store the tetramer at 4°C and avoid freeze-thaw cycles to retain its integrity. Aliquoting for long-term storage can pQAent degradation and ensure reproducibility in experimental results.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
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COA
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